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Important Safety Information
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The journey to a CSID diagnosis. 
CSID is mainly a clinical diagnosis.

It is easy for a doctor to initially miss or delay a diagnosis of Congenital Sucrase-Isomaltase 
Deficiency (CSID), especially if the patient has mild, nonspecific symptoms.

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If you have been diagnosed with CSID, ask your GI doctor if Sucraid® is right for you.

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A correct diagnosis of 
CSID may be delayed.

When a doctor sees a cluster of symptoms, they look first for a more likely diagnosis before looking for a less common one. They run a number of tests to rule out other more common causes of severe, chronic diarrhea and other gastrointestinal (GI) symptoms.

Most individuals who have CSID begin their diagnostic journey in the office of their pediatrician or primary care physician. Typically, these doctors will suspect the diagnosis is one of several more common conditions that cause diarrhea. These can include the catch-all diagnosis, toddler’s diarrhea, which is the name for chronic, nonspecific diarrhea. Other common diagnoses include irritable bowel syndrome, a condition possibly related to intestinal inflammation that can cause either chronic diarrhea or constipation; the presence of intestinal parasites (organisms that can infect the intestines); or other intestinal infections. When treatments, such as antibiotics, for these more common conditions do not relieve the symptoms, doctors often will refer the patient to a gastroenterologist, a physician who specializes in ailments of the digestive system.

The gastroenterologist will usually begin with a routine analysis of the patient’s well-being, including a physical examination, history of medical conditions, symptoms or complaints, family history, and dietary history. The physician may order a series of tests to determine the exact diagnosis.

Diagnostic tools to assess 
sucrase enzyme activity

While no test on the market today is 100% accurate, and current tests, including genetic testing, cannot rule out secondary sucrase deficiency, several options are available to help assess the likelihood of a CSID diagnosis.

Biopsy

Disaccharidase (including sucrase) assay via small bowel biopsy 
Contact your local Quest Diagnostics® or LabCorp representative

13C-sucrose breath test (13C-SBT) 
Metabolic Solutions, 1-603-598-6960

Sucrose hydrogen-methane breath test 
Aerodiagnostics™, 1-617-608-3832
Commonwealth Labs, 1-888-258-5966 
Metabolic Solutions, 1-603-598-6960
Trio-Smart®, 1-855-888-1230
Food Marble, [email protected]

Find out more: sucrosechallenge.com

Congenital Sucrase-Isomaltase Deficiency (SI Gene) Test 
Contact your local genetic testing lab

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How to Order
Important Safety Information
Sucraid® (sacrosidase) Oral Solution
  • Tell your doctor if you are allergic to, have ever had a reaction to, or have ever had difficulty taking yeast, yeast products, papain, or glycerin (glycerol).
  • Sucraid® may cause a serious allergic reaction. If you notice any swelling or have difficulty breathing, get emergency help right away.
  • Sucraid® does not break down some sugars that come from the digestion of starch. You may need to restrict the amount of starch in your diet. Your doctor will tell you if you should restrict starch in your diet.
  • Tell your doctor if you have diabetes, as your blood glucose levels may change if you begin taking Sucraid®. Your doctor will tell you if your diet or diabetes
    medicines need to be changed.
  • Some patients treated with Sucraid® may have worse abdominal pain, vomiting, nausea, or diarrhea. Constipation, difficulty sleeping, headache,
    nervousness, and dehydration have also occurred in patients treated with Sucraid®. Check with your doctor if you notice these or other side effects.
  • Sucraid® has not been tested to see if it works in patients with secondary (acquired) sucrase deficiency.
  • NEVER HEAT SUCRAID® OR PUT IT IN WARM OR HOT BEVERAGES OR INFANT FORMULA. Do not mix Sucraid® with fruit juice or take it with fruit juice. Take Sucraid® as prescribed by your doctor. Normally, half of the dose of Sucraid® is taken just before a meal or snack and the other half is taken during the meal or snack.
  • Sucraid® should be refrigerated at 36°F-46°F (2°C-8°C) and should be protected from heat and light; single-use containers can be removed from refrigeration and stored at 59°F-77°F (15°C-25°C) for up to 3 days (72 hours). Refer to Instructions for Use for full information on how to take Sucraid®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Indication

Sucraid® (sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of
Congenital Sucrase-Isomaltase Deficiency (CSID).

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